EC Number   |
Protein Variants |
Reference |
|---|
   2.4.2.60 | A140V |
complete loss of activity, leading to disruption of the thiamine biosynthetic route |
745278 |
| 2.4.2.60 | A140V |
mutant contains more sulfur-containing cysteines than wild-type, and its conformational stability is affected |
744389 |
| 2.4.2.60 | C204A |
mutant catalyzes the release of the nicotinamide moiety from NAD to produce ADP-ribose, which is further converted to ADP-ribulose. In the presence of glycine, mutant catalyzes the formation of an advanced intermediate |
745151 |
| 2.4.2.60 | C204A |
partially active mutant |
745881 |
| 2.4.2.60 | C205S |
the mutant is catalytic in the presence of exogenous sulfide |
744348 |
| 2.4.2.60 | C207A |
inactive |
744348 |
| 2.4.2.60 | D33G |
no significant effect on activity |
745278 |
| 2.4.2.60 | D41G |
no significant effect on activity |
745278 |
| 2.4.2.60 | E222G |
complete loss of activity, leading to disruption of the thiamine biosynthetic route |
745278 |
| 2.4.2.60 | G77V |
complete loss of activity, leading to disruption of the thiamine biosynthetic route |
745278 |
