EC Number |
Protein Variants |
Reference |
---|
2.4.1.83 | C172S |
specific activity similar to the wild-type enzyme |
489457 |
2.4.1.83 | C259S |
specific activity similar to the wild-type enzyme |
489457 |
2.4.1.83 | C93S |
specific activity similar to the wild-type enzyme |
489457 |
2.4.1.83 | D38A |
5.8% of the activity of wild-type |
692257 |
2.4.1.83 | D39A |
2% of the activity of wild-type |
692257 |
2.4.1.83 | D89A |
0.09% of the activity of wild-type |
692257 |
2.4.1.83 | D91A |
0.17% of the activity of wild-type |
692257 |
2.4.1.83 | G10E |
Lec15.1 cell have a single point mutation within the coding region of DPM2 gene. The mutant DPM2 cDNA is expresses a drastically reduced amount of DPM2 protein |
657759 |
2.4.1.83 | I253N |
higher value for the apparent Km-value for dolichyl phosphate when assayed in detergent solution, mutation has no effect on Km-value when the enzyme is reconstituted with phosphatidylethanolamine |
489442 |
2.4.1.83 | more |
cloned Pfdpm1 gene fails to complement a Saccharomyces cerevisiae mutant indicating that the parasite gene does not belong to the bakerยs yeast group. Furthermore, Pfdpm1 is unable to complement a mouse mutant deficient in DPM but efficiently complements the Schizosaccharomyces pombe fission yeast mutant, indicating a difference between fission yeast and mammalian DPM genes |
690729 |