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EC Number
Protein Variants
Commentary
Reference
2.4.1.269
D100A
inactive mutant enzyme
710045
2.4.1.269
D102A
completely inactive in the presence of all metals tested
722705
2.4.1.269
D102A
inactive mutant enzyme
710045
2.4.1.269
D135A
very high Km value for D-glycerate and a slight increase in kcat
722705
2.4.1.269
D192A
inactive
722705
2.4.1.269
E166A
15-fold increase in Km for glycerate
722705
2.4.1.269
H217A
inactive mutant enzyme
710045
2.4.1.269
H217A
significant change in metal preference. Mutant is essentially inactive in the presence of Ca2+, whereas the kcat value is reduced 23-fold in the presence of Mg2+
722705
2.4.1.269
K76A
3-4-fold increase in kcat coupled with an elevation in Km for D-glycerate and GDP-Man of 15- and 3-fold, respectively
722705
2.4.1.269
K9A
significant increase in kcat, little effect on the Km value for GDP-Man
722705
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