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Results 1 - 5 of 5
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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.B8more generation of chimeric E2 enzymes consisting of different parts of human UbcH5 and murine UbcM3. Chimera consist of the N-terminal 62 amino acids of UbcH5 fused to the C-terminal 85 amino acids of UbcM3 and of the N-terminal 108 amino acids of UbcM3 fused to the C-terminal 85 amino acids of UbcH5, respectively. The ability to interact with E3 enzyme E6-AP maps to the C-terminal 85 amino acids of UbcH5 651978
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.B8more generation of chimeric E2 enzymes consisting of different parts of human UbcH5 and murine UbcM3. Chimera consist of the N-terminal 62 amino acids of UbcH5 fused to the C-terminal 85 amino acids of UbcM3 and of the N-terminal 108 amino acids of UbcM3 fused to the C-terminal 85 amino acids of UbcH5, respectively. The ability to interact with E3 enzyme E6-AP maps to the C-terminal 85 amino acids of UbcH5 and particularly to a phenylalanine residue at position 62 of UbcH5 that is conserved among the members of the UBC4/UBC5 subfamily but is not present in any of the other known E2 enzymes 651978
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.B8R600A this HECT-domain mutant is inactive 736486
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.B8S68A the mutant shows wild type activity 736634
Display the word mapDisplay the reaction diagram Show all sequences 2.3.2.B8Y763A this HECT-domain mutant is inactive 736486
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