EC Number   |
Protein Variants |
Reference |
|---|
   2.3.2.27 | A46P |
the mutant shows barely detectable autoubiquitination activity compared to the wild type |
736504 |
| 2.3.2.27 | C11A |
mutation introduced to reduce the stability of the RING domain, poor activity |
733258 |
| 2.3.2.27 | C132S |
mutation in the RING domain, loss of E3 ubiquitin ligase activity |
734913 |
| 2.3.2.27 | C149A |
mutation in RING domain, inactive |
758093 |
| 2.3.2.27 | C15A |
mutation in the conserved RING-finger domain, loss of autoubiquitination ability |
692286 |
| 2.3.2.27 | C172A |
mutation in the RING domain, mutant does not show autoubiquitylation |
734386 |
| 2.3.2.27 | C194S |
mutation in highly conserved residue, loss of ubiqitin ligase activity |
728278 |
| 2.3.2.27 | C196A |
amino acid substitution of the RING domain, complete loss of E3 ligase activity |
734992 |
| 2.3.2.27 | C197S |
mutation in highly conserved residue, loss of ubiqitin ligase activity |
728278 |
| 2.3.2.27 | C367S |
mutation within RING finger domain, mutant protein does not display significant ubiquitin ligase activity |
734805 |
