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EC Number Protein Variants Commentary Reference
Show all pathways known for 2.3.1.220Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.220A257G site-directed mutagenesis, altered substrate entrance in the active site structure compared to the wild-type enzyme. The mutant A257G gives similar enzyme products as the wild type with both benzoyl-CoA and 4-coumaroyl-CoA 720639
Show all pathways known for 2.3.1.220Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.220G339S site-directed mutagenesis, altered substrate entrance in the active site structure compared to the wild-type enzyme. The mutant G339S yields high amounts of both benzophenone and triketide lactone type with benzoyl-CoA but shows no activity for 4-coumaroyl-CoA 720639
Show all pathways known for 2.3.1.220Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.220G339V site-directed mutagenesis, altered substrate entrance in the active site structure compared to the wild-type enzyme. The mutant shows no activity with either benzoyl-CoA or 4-coumaroyl-CoA 720639
Show all pathways known for 2.3.1.220Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.220more homology model of wild-type GmBPS and GmBPS mutants A257G, T133L, G339V, and G339S, active-site architectures by surface models and substrate entrances, overview 720639
Show all pathways known for 2.3.1.220Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.220T133L site-directed mutagenesis, altered substrate entrance in the active site structure compared to the wild-type enzyme. With benzoyl-CoA as a starter, the T133L mutant yields triketide lactone as the major enzymatic product 720639
Show all pathways known for 2.3.1.220Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.220T135A site-directed mutagenesis, inactive mutant 706131
Show all pathways known for 2.3.1.220Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.220T135F site-directed mutagenesis, the mutant functionally resembles the wild-type enzyme 706131
Show all pathways known for 2.3.1.220Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.220T135G site-directed mutagenesis, inactive mutant 706131
Show all pathways known for 2.3.1.220Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.220T135I site-directed mutagenesis, inactive mutant 706131
Show all pathways known for 2.3.1.220Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.220T135L site-directed mutagenesis, the benzophenone synthaase is converted into a functional phenylpyrone synthase by the single amino acid substitution in the initiation/elongation cavity, chalcone synthase-based homology modeling, overview. The intermediate triketide may be redirected into a smaller pocket in the active site cavity, resulting in phenylpyrone formation by lactonization. Compared with the initiation/elongation cavity of BPS, the size of the newly accessible pocket in PPS is smaller and does not allow for a third acetyl addition to the growing polyketide chain, resulting in the release of the intermediate triketide as 6-phenyl-4-hydroxy-2-pyrone 706131
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