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Results 1 - 9 of 9
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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.137C323M site-directed mutagenesis, crystal structure comparison with the wild-type enzyme, altered acyl-CoA substrate specificity compared to the wild-type enzyme, highly increased specificity for octanoyl-CoA 659511
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.137G553M site-directed mutagenesis, highly reduced activity with altered acyl-CoA substrate specificity compared to the wild-type enzyme 659511
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.137G553M site-directed mutagenesis, the mutant enzyme shows altered substrate specificity: highly reduced activity with medium- and long-chain acyl-CoAs and increased activity with acetyl-CoA and butanoyl-CoA compared to the wild-type enzyme 659372
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.137M335A site-directed mutagenesis, reduced activity with altered acyl-CoA substrate specificity compared to the wild-type enzyme 659511
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.137M335V site-directed mutagenesis, crystal structure comparison with the wild-type enzyme, highly reduced activity with altered acyl-CoA substrate specificity compared to the wild-type enzyme 659511
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.137more the carnitine acetyl-transferase, specific for acetyl-CoA/short-chain acyl-CoAs, can be modified to an enzyme with elevated carnitine octanoyltransferase activity by mutation of Met564 to Gly, overview 659372
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.137R518N site-directed mutagenesis, mutant shows 1650fold increased Km for L-carnitine, only slightly affected Km for acyl-CoA and kcat compared to the wild-type enzyme 657546
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.137S552A site-directed mutagenesis, mutant shows 17fold increased Km for L-carnitine compared to the wild-type enzyme 657546
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.137S554X site-directed mutagenesis, mutant shows 10fold decreased kcat compared to the wild-type enzyme 657546
Results 1 - 9 of 9
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