EC Number   |
Protein Variants |
Reference |
|---|
   2.1.1.348 | D377A |
the METTL3 mutation completely abolishes enzyme activity |
757800 |
| 2.1.1.348 | D395A |
change of the DPPW catalytic motif to APPW in METTL3, abrogates the ability of its complex with wild type METTL14 to methylate RNA |
745758 |
| 2.1.1.348 | D395A |
the METTL3 mutation completely abolishes enzyme activity |
757800 |
| 2.1.1.348 | D395A/A398A |
catalytically inactive |
745757 |
| 2.1.1.348 | E192A |
change of EPPL to APPL in METTL14, little effect on methylation capacity if wild type METTL3 is present |
745758 |
| 2.1.1.348 | E532A |
the METTL3 mutation completely abolishes enzyme activity |
757800 |
| 2.1.1.348 | H538A |
the METTL3 mutation moderately reduces enzyme activity |
757800 |
| 2.1.1.348 | K177R/K211R/K212R/K215R |
mutation in subunit METTL3. SUMOylation of the mutant is reduced compared to that of METTL3 wild-type in H1299 stable cell lines |
745930 |
| 2.1.1.348 | N539A |
the METTL3 mutation completely abolishes enzyme activity |
757800 |
| 2.1.1.348 | N549A |
the METTL3 mutation moderately reduces enzyme activity |
757800 |
