EC Number   |
Protein Variants |
Reference |
|---|
   1.14.11.67 | A388P |
the mutant shows 14.4% of wild type activity with [histone H3]-N6,N6-dimethyl-L-lysine4 and 45.1% of wild type activity with [histone H3]-N6,N6,N6-trimethyl-L-lysine4 |
756363 |
| 1.14.11.67 | D328A |
site-directed mutagenesis, a loss-of-function mutations in the PHD1 finger domain |
744657 |
| 1.14.11.67 | D939R |
the mutation increases the Kd of JMJD2A for H4K20me3 by about 200fold but does not markedly change the affinity for H3K4me3 |
700373 |
| 1.14.11.67 | D945R |
the mutation increases the Kd of JMJD2A for H3K4me3 by about 200fold, but does not affect the interaction with H4K20me3 |
700373 |
| 1.14.11.67 | E396A |
site directed mutagenesis of a Fe2+ binding active site residue, inactive mutant, the mutation impairs the H3K4 demethylase activity of JMJ703 in tobacco cells |
726261 |
| 1.14.11.67 | F279S |
catalytically lethal mutant |
744413 |
| 1.14.11.67 | F642L |
the mutant shows 40.1% of wild type activity with [histone H3]-N6,N6-dimethyl-L-lysine4 and 71.6% of wild type activity with [histone H3]-N6,N6,N6-trimethyl-L-lysine4 |
756363 |
| 1.14.11.67 | G376A |
site directed mutagenesis, inactive mutant, the mutation impairs the H3K4 demethylase activity of JMJ703 in tobacco cells, the mutation impairs the H3K4 demethylase activity of JMJ703 in tobacco cells |
726261 |
| 1.14.11.67 | H18G |
the mutation increases the Kd for H3K4me3 by fivefold compared to the wild-type enzyme |
700373 |
| 1.14.11.67 | H394A |
site directed mutagenesis of a Fe2+ binding active site residue, inactive mutant |
726261 |
