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EC Number
Protein Variants
Commentary
Reference
1.14.11.54
D135I
the mutant shows increased activity with RNA-N6-methyladenine and reduced activity with DNA-N1-methyladenine compared to the wild type enzyme
741601
1.14.11.54
D135N
the mutant shows increased activity with RNA-N6-methyladenine and reduced activity with DNA-N1-methyladenine compared to the wild type enzyme
741601
1.14.11.54
E136L
the mutant shows increased activity with RNA-N6-methyladenine and reduced activity with DNA-N1-methyladenine compared to the wild type enzyme
741601
1.14.11.54
L177A
mutation at the active site, mutant lost its demethylation activity on m1A of tRNA in vitro and in vivo
765483
1.14.11.54
R122A
mutant is defective in its DNA/RNA binding groove, mutant lost its demethylation activity on m1A of tRNA in vitro and in vivo
765483
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