EC Number   |
Protein Variants |
Reference |
|---|
   1.14.11.53 | 269A/Q271A |
double mutation shows no impact on the repair efficiency of Alkbh5 |
738609 |
| 1.14.11.53 | E153A |
mutant enzyme displays activity similar to wild type |
738615 |
| 1.14.11.53 | F232A/F234A |
mutant exhibits 41% activity toward m6A-containing ssDNA |
738609 |
| 1.14.11.53 | F232D/Q233D/F234E |
the mutant enzyme displays a severe loss of activity, demonstrating only 13.5% of wild-type activity |
738609 |
| 1.14.11.53 | H204A |
inactive mutant enzyme |
739064 |
| 1.14.11.53 | H231A/D233A |
inactive |
743373 |
| 1.14.11.53 | H231A/D233A |
mutant completely loses m6A demethylation activity |
739140 |
| 1.14.11.53 | H266A |
activity is significantly compromised |
739064 |
| 1.14.11.53 | I209D |
the mutant shows decreased activity compared to the wild type enzyme |
737446 |
| 1.14.11.53 | I209E |
the mutant shows decreased activity compared to the wild type enzyme |
737446 |
