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Results 1 - 4 of 4
EC Number Protein Variants Commentary Reference
Show all pathways known for 1.13.11.73Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.73E176H site-directed mutagenesis, the HEPD, EC 1.13.11.72, mutant is bifunctional exhibiting the activity of both 2-hydroxyethylphosphonate dioxygenase (HEPD) and methylphosphonate synthase (MPnS). The product distribution of the mutant is sensitive to a substrate isotope effect, consistent with an isotope-sensitive branching mechanism involving a common intermediate. The introduced histidine does not coordinate the active site metal, unlike the iron-binding glutamate it replaces. More HEPD activity is observed when the reaction is carried out with (R)-2-[2-2H1]-hydroxyethylphosphonate 745162
Show all pathways known for 1.13.11.73Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.73Q152D the mutant shows weakened activity compared to the wild type enzyme 764510
Show all pathways known for 1.13.11.73Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.73Q152E inactive 764510
Show all pathways known for 1.13.11.73Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.73Q152H the mutant shows weakened activity compared to the wild type enzyme 764510
Results 1 - 4 of 4