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Results 1 - 10 of 26 > >>
EC Number Protein Variants Commentary Reference
Show all pathways known for 1.13.11.40Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.40A417G converts arachidonic acid mainly to 12-hydroxyeicosatetraenoic acid, mutant retains 38% of catalytic efficiency 660365
Show all pathways known for 1.13.11.40Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.40A417S same oxygenase specificity and similar catalytic activity to wild-type 8S-LOX 660365
Show all pathways known for 1.13.11.40Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.40A589M site-directed mutagenesis, the mutant shows reduced activity and altered protein fold compared to the wild-type enzyme 742865
Show all pathways known for 1.13.11.40Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.40A592M stability of the enzyme-substrate complex is similar to wild-type. Contrary to wild-type, hydrogen abstraction from C13 is more favorable in the mutant. A592M yields 19% 8R product, 2% 8S, 60% 11R, 4% 11S, plus some 12R/12S and 15R/15S product 765268
Show all pathways known for 1.13.11.40Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.40A620H site-directed mutagenesis, the mutant shows reduced activity and altered protein fold compared to the wild-type enzyme 742865
Show all pathways known for 1.13.11.40Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.40A623H stability of the enzyme-substrate complex is similar to wild-type. Contrary to wild-type, hydrogen abstraction from C13 is more favorable in the mutant. A623H yields 16% 8R product, 4% 8S, 57% 11R, 5% 11S, 6% 12R, 6% 12S plus some 15R/15S product 765268
Show all pathways known for 1.13.11.40Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.40D39A 118% activity compared to the wild type enzyme, mutant with diminished fluorescence resonance energy transfer properties, consistent with a role for calcium in membrane binding 674505
Show all pathways known for 1.13.11.40Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.40D39A/E47A 106% activity compared to the wild type enzyme, a double mutant with calcium-binding residues from two of the three sites mutated exhibits no fluorescence resonance energy transfer signal 674505
Show all pathways known for 1.13.11.40Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.40E47A 65% of the activity of the wild type enzyme, mutant with diminished fluorescence resonance energy transfer properties, consistent with a role for calcium in membrane binding 674505
Show all pathways known for 1.13.11.40Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.40G427A site-directed mutagenesis. In wild-type, molecular oxygen adds to C8 of arachidonic acid with an R stereochemistry. In the mutant, Ala427 pushes Leu385, blocks the region over C8, and opens an oxygen access channel now directed to C12, where molecular oxygen is added with an S stereochemistry. Thus, the specificity turns out to be dramatically inverted 741487
Results 1 - 10 of 26 > >>