EC Number   |
Protein Variants |
Reference  |
|---|
   2.7.8.27 | more |
sphingomyelin synthase 2 deficiency, due to siRNA treatment of HEK-293 cells, attenuates NFkappaB activation, it impairs TNF receptor 1 recruitment tolipid rafts and TLR4-MD2 complex recruitment to plasma membrane |
690656 |
| 2.7.8.27 | more |
sphingomyelin synthase 2 knockout deficiency attenuates NFkappaB activation, it impairs TNF receptor 1 recruitment tolipid rafts and TLR4-MD2 complex recruitment to plasma membrane |
690656 |
| 2.7.8.27 | more |
overexpression of SMS1 in Jurkat cells leads to suppression of the production of dihydroceramides and dihydrosphingosine, and ceramide |
690695 |
| 2.7.8.27 | more |
S49AR cells show a defect in the synthesis of sphingomyelin and downregulated SMS1, phenotype, overview. Resistance to ALP can be mimicked by small interfering RNA-induced SMS1 suppression, resulting in sphingomyelin deficiency and blockage of raft-dependent internalization of ALP and induction of apoptosis, overview |
690804 |
| 2.7.8.27 | more |
downregulation of SMS1 or SMS2 by siRNA oligonucleotides targeting SMS1 or SMS2 in HeLA cells reduces de novo synthesis of sphingomyelin, overview |
690832 |
| 2.7.8.27 | more |
downregulation of SMS in Huh7 cells by expression of siRNA, overview |
691046 |
| 2.7.8.27 | H285A |
site-directed mutagenesis, inactive mutant with wild-type localization pattern, overview. The point mutation only influences SMS2 catalytic activity but not the enzyme topology |
691074 |
| 2.7.8.27 | H328A |
site-directed mutagenesis, inactive mutant with wild-type localization pattern, overview. The point mutation only influences SMS2 catalytic activity but not the enzyme topology |
691074 |
| 2.7.8.27 | H332A |
site-directed mutagenesis, inactive mutant with wild-type localization pattern, overview. The point mutation only influences SMS2 catalytic activity but not the enzyme topology |
691074 |
| 2.7.8.27 | S273A |
site-directed mutagenesis, inactive mutant with wild-type localization pattern, overview. The point mutation only influences SMS2 catalytic activity but not the enzyme topology |
691074 |
