EC Number   |
Protein Variants |
Reference |
|---|
   2.7.8.27 | more |
construction of an SMS1 interference vector, enzyme silencing by shRNA in Hep-G2 cells leading a downregulation rate of 45% and reduced enzyme activity of 56% |
738307 |
| 2.7.8.27 | more |
construction of an SMS2 interference vector, enzyme silencing by shRNA in Hep-G2 cells leading to a downregulation rate of 67% and reduced enzyme activity of 63% |
738307 |
| 2.7.8.27 | more |
downregulation of SMS in Huh7 cells by expression of siRNA, overview |
691046 |
| 2.7.8.27 | more |
downregulation of SMS1 or SMS2 by siRNA oligonucleotides targeting SMS1 or SMS2 in HeLA cells reduces de novo synthesis of sphingomyelin, overview |
690832 |
| 2.7.8.27 | more |
endogenous SMS2 expression in HeLa cells is reduced by about 80% after treatment with SMS2 siRNA, but is unaffected after treatment with lamin A or SMS1 siRNAs. Impact of SMS1 and SMS2 depletion on the lipid composition of HeLa cells, overview |
692991 |
| 2.7.8.27 | more |
generation of SMS2 KO mice |
-, 737776 |
| 2.7.8.27 | more |
knockout of SMS1 in T-cells by transfection of SMS1-short-interfering RNA into Jurkat T cells, impaired TCR signaling through dysfunction of lipid rafts in SMS1-knockdown T cells, overview. CD3-induced tyrosine phosphorylation and association of linker for activation of T cell with ZAP-70 and Grb2 and phosphorylation of protein kinase C are also severely impaired in Jurkat-SMS1/kd cells |
692624 |
| 2.7.8.27 | more |
overexpression of SMS1 in Jurkat cells leads to suppression of the production of dihydroceramides and dihydrosphingosine, and ceramide |
690695 |
| 2.7.8.27 | more |
overexpression of SMS1 is accompanied by attenuated ceramide response and apoptotic resistance after photodamage with the photosensitizer Pc 4, while suppression of SMS1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage, overview |
692213 |
| 2.7.8.27 | more |
S49AR cells show a defect in the synthesis of sphingomyelin and downregulated SMS1, phenotype, overview. Resistance to ALP can be mimicked by small interfering RNA-induced SMS1 suppression, resulting in sphingomyelin deficiency and blockage of raft-dependent internalization of ALP and induction of apoptosis, overview |
690804 |
