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EC Number Protein Variants Commentary Reference
Show all pathways known for 2.7.6.2Display the word mapDisplay the reaction diagram Show all sequences 2.7.6.2D100N mutation reduces turnover-number markedly 642743
Show all pathways known for 2.7.6.2Display the word mapDisplay the reaction diagram Show all sequences 2.7.6.2D133N mutation causes a selective decrease in the ratio of turnover-number to Km-value for thiamine 642743
Show all pathways known for 2.7.6.2Display the word mapDisplay the reaction diagram Show all sequences 2.7.6.2D71N mutation reduces turnover-number markedly 642743
Show all pathways known for 2.7.6.2Display the word mapDisplay the reaction diagram Show all sequences 2.7.6.2D73N mutation reduces turnover-number markedly 642743
Show all pathways known for 2.7.6.2Display the word mapDisplay the reaction diagram Show all sequences 2.7.6.2Q96E mutation causes an 2.5fold increase in the ratio of turnover-number to Km-value for thiamine compared to the wild-type 642743
Show all pathways known for 2.7.6.2Display the word mapDisplay the reaction diagram Show all sequences 2.7.6.2R131G mutation decreases the ratio of turnover-number to Km-value for ATP 642743
Show all pathways known for 2.7.6.2Display the word mapDisplay the reaction diagram Show all sequences 2.7.6.2S74A mutation causes a 1.4fold increase in turnover number, the Km-value for ATP is 2fold that of the wild-type enzyme 642743
Show all pathways known for 2.7.6.2Display the word mapDisplay the reaction diagram Show all sequences 2.7.6.2T99A mutation decreases the ratio of turnover-number to Km-value for ATP 642743
Show all pathways known for 2.7.6.2Display the word mapDisplay the reaction diagram Show all sequences 2.7.6.2more construction of a double knockout mutant lacking isozymes TPK1 and TPK2, the mutant shows severely depressed levels of TPP and elevated levels of free thiamine compared to the wild-type enzyme 676560
Show all pathways known for 2.7.6.2Display the word mapDisplay the reaction diagram Show all sequences 2.7.6.2more three common intronic variants in the maternal and fetal thiamine pyrophosphokinase gene (TPK1) are associated with birth weight, overview 695592
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