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EC Number
Protein Variants
Commentary
Reference
2.7.4.8
S80A
sluggish enzyme
642701
2.7.4.8
Y78F
affinity for MgATP2- similar to wild type but affinity for GMP decreases by a factor of 12
642702
2.7.4.8
D103N
active
642706
2.7.4.8
E72Q
no guanylate or adenylate kinase activity
642706
2.7.4.8
E72Q/D103D
no active
642706
2.7.4.8
P564S/S631D
PSD-95 construct
662176
2.7.4.8
S35P
reduced activity
662176
2.7.4.8
S35P/D101S
reduced activity
662176
2.7.4.8
more
construction of mutant PSD-95 SH3-GK which contains a deleterious point mutation in the C-terminal SH3 domain
676138
2.7.4.8
D74A
site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme
700079
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