EC Number   |
Protein Variants |
Reference |
|---|
    2.7.4.8 | D103N |
active |
642706 |
| 2.7.4.8 | Y78F |
affinity for MgATP2- similar to wild type but affinity for GMP decreases by a factor of 12 |
642702 |
| 2.7.4.8 | more |
construction of mutant PSD-95 SH3-GK which contains a deleterious point mutation in the C-terminal SH3 domain |
676138 |
| 2.7.4.8 | G3A |
decrease in Tm-value by 1.4°C as compared to wild-type enzyme. Decrease in catalytic efficiency (kcat/Km) by 14% |
761496 |
| 2.7.4.8 | R116Q |
decrease in Tm-value by 1.8°C as compared to wild-type enzyme. Decrease in catalytic efficiency (kcat/Km) by 18% |
761496 |
| 2.7.4.8 | S2L |
decrease in Tm-value by 1.9°C as compared to wild-type enzyme. Decrease in catalytic efficiency (kcat/Km) by 11% |
761496 |
| 2.7.4.8 | S186Y |
decrease in Tm-value by 2.8°C as compared to wild-type enzyme. Decrease in catalytic efficiency (kcat/Km) by 7% |
761496 |
| 2.7.4.8 | S121F |
decrease in Tm-value by 3.6°C as compared to wild-type enzyme. Decrease in catalytic efficiency (kcat/Km) by 25% |
761496 |
| 2.7.4.8 | V91M |
decrease in Tm-value by 3°C as compared to wild-type enzyme. Decrease in catalytic efficiency (kcat/Km) by 14% |
761496 |
| 2.7.4.8 | R96H |
decrease in Tm-value by 4°C as compared to wild-type enzyme. Increase in catalytic efficiency (kcat/Km) by 22% |
761496 |
