EC Number   |
Protein Variants |
Reference  |
|---|
   2.3.1.B41 | H131Y |
the mutant enzyme can still bind NAD+ but has a decreased ability to bind ADP-ribose |
729972 |
| 2.3.1.B41 | H133Y |
when human Sirt6 wild-type enzyme is overexpressed in Sirt6 KO MEF cells, tumor necrosis factor alpha has lower fatty acylation level than tumor necrosis factor alpha from cells without overexpression of human Sirt6, while overexpression of human Sirt6 H133Y catalytic mutant does not have much effect on tumor necrosis factor alpha fatty acylation |
730464 |
| 2.3.1.B41 | M70R |
further decrease in nicotinamide sensitivity compared to wild-type |
730706 |
| 2.3.1.B41 | G60A |
inactive |
737946 |
| 2.3.1.B41 | Y12F |
the mutant exhibits deacetylase activity similar to that of the wild type enzyme |
738283 |
| 2.3.1.B41 | Y148F |
the mutant shows 57% decrease of activity compared to the wild type enzyme |
738283 |
| 2.3.1.B41 | Y257F |
the mutant shows 73% decrease of activity compared to the wild type enzyme |
738283 |
| 2.3.1.B41 | Y5F |
the mutant exhibits deacetylase activity similar to that of the wild type enzyme |
738283 |
| 2.3.1.B41 | G60A |
the mutant is a lysine defatty acylase in vitro with substantially decreased deacetylase activity in vitro and no detectable deacetylase activity in cells |
739139 |
| 2.3.1.B41 | H133Y |
inactive |
739139, 739158 |
