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Results 1 - 10 of 12 > >>
EC Number
Amino acid exchange
Commentary
Reference
G60A
inactive
G60A
the mutant is a lysine defatty acylase in vitro with substantially decreased deacetylase activity in vitro and no detectable deacetylase activity in cells
H131Y
the mutant enzyme can still bind NAD+ but has a decreased ability to bind ADP-ribose
H133Y
inactive
H133Y
when human Sirt6 wild-type enzyme is overexpressed in Sirt6 KO MEF cells, tumor necrosis factor alpha has lower fatty acylation level than tumor necrosis factor alpha from cells without overexpression of human Sirt6, while overexpression of human Sirt6 H133Y catalytic mutant does not have much effect on tumor necrosis factor alpha fatty acylation
M70R
further decrease in nicotinamide sensitivity compared to wild-type
R65A
the mutant shows only ADP-ribosyltransferase activity but no deacetylase activity
S56Y
inactive
Y12F
the mutant exhibits deacetylase activity similar to that of the wild type enzyme
Y148F
the mutant shows 57% decrease of activity compared to the wild type enzyme
Results 1 - 10 of 12 > >>