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EC Number Protein Variants Commentary Reference
Show all pathways known for 4.2.1.96Display the word mapDisplay the reaction diagram Show all sequences 4.2.1.96N61D The decreased ability of the N61D mutant to affect HNF1alpha-dependent DNA binding is likely a direct result of altered quaternary structure. 690623
Show all pathways known for 4.2.1.96Display the word mapDisplay the reaction diagram Show all sequences 4.2.1.96N61D/Q45R/K98Q site-directed mutagenesis, triple DCoHa mutant (Q45R/K98Q/N61D) is unable to affect HNF1alpha-dependent DNA binding in vitro. 690623
Show all pathways known for 4.2.1.96Display the word mapDisplay the reaction diagram Show all sequences 4.2.1.96Q45R/K98Q mutant Q45R/K98Q is not able to affect HNF1alpha-dependent DNA binding in vitro 690623
Show all pathways known for 4.2.1.96Display the word mapDisplay the reaction diagram Show all sequences 4.2.1.96T51S the point mutation at the enzyme tetramer interface overcomes the dissociation barrier of the homotetramer and increases the interaction with HNF-1alpha. Presence of an ordered water molecule at the tetramer interface, which may destabilize the homotetramer 714176
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