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<< < Results 11 - 20 of 38 > >>
EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.45G332A site-directed mutagenesis, replacement of Gly332 with the larger hydrophobic residue selectively augments dehydration of (9Z,11E,13R,15Z)-13-hydroperoxyoctadeca-9,12,15-trienoic acid and increases the oxidation at C-13 of 18:1n-6 725486
Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.45H274Q no enzymic activity, loss of more than 95% of manganese content 654377
Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.45H278E no enzymic activity, loss of more than 95% of manganese content 654377
Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.45H462E no enzymic activity, loss of more than 95% of manganese content 654377
Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.45H463Q no significant change in activity 654377
Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.45I296A site-directed mutagenesis, structure comparison with wild-type enzyme, the stereospecificity of the mutant activity is inverted compared to the wild-type enzyme 743826
Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.45K52N site-directed mutagenesis 725486
Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.45L176K site-directed mutagenesis 725486
Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.45L258V site-directed mutagenesis, structure comparison with wild-type enzyme, the mutation only slightly affects the enzyme activity 743826
Display the word mapDisplay the reaction diagram Show all sequences 1.13.11.45L336A site-directed mutagenesis, replacement of Leu336 with the smaller hydrophobic residue shifts the oxygenation from C-13 toward C-9 with formation of 9S- and 9R-hydroperoxy metabolites of 18:2n-6 and 18:3n-3, the mutant shows highly reduced activity compared to the wild-type enzyme 725486
<< < Results 11 - 20 of 38 > >>