EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
    4.1.1.45 | aminocarboxymuconate-semialdehyde decarboxylase deficiency |
23955123 |
The ACMSD gene, involved in tryptophan metabolism, is mutated in a family with cortical myoclonus, epilepsy, and parkinsonism. |
causal interaction
unassigned |
4
0 |
| 4.1.1.45 | Brain Neoplasms |
23144293 |
The kynurenine pathway in brain tumor pathogenesis. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 4.1.1.45 | Carcinoma, Hepatocellular |
11802786 |
Purification and molecular cloning of rat 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase. |
ongoing research
unassigned |
4
0 |
| 4.1.1.45 | Diabetes Mellitus, Experimental |
7671148 |
Effect of dietary linoleic acid on the tryptophan-niacin metabolism in streptozotocin diabetic rats. |
ongoing research
unassigned |
4
0 |
| 4.1.1.45 | Epilepsies, Myoclonic |
23955123 |
The ACMSD gene, involved in tryptophan metabolism, is mutated in a family with cortical myoclonus, epilepsy, and parkinsonism. |
causal interaction
unassigned |
4
0 |
| 4.1.1.45 | Malaria, Cerebral |
19843166 |
The crystal structure of human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis. |
therapeutic application
unassigned |
4
0 |
| 4.1.1.45 | Nervous System Diseases |
19843166 |
The crystal structure of human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis. |
therapeutic application
unassigned |
4
0 |
| 4.1.1.45 | Nervous System Diseases |
23209189 |
Genome-wide association study for type 2 diabetes in indians identifies a new susceptibility locus at 2q21. |
unassigned |
0 |
| 4.1.1.45 | Neurodegenerative Diseases |
30380424 |
Alpha-Amino-Beta-Carboxy-Muconate-Semialdehyde Decarboxylase Controls Dietary Niacin Requirements for NAD+ Synthesis. |
unassigned |
0 |
| 4.1.1.45 | Parkinson Disease |
28671144 |
A Novel p.Glu298Lys Mutation in the ACMSD Gene in Sporadic Parkinson's Disease. |
causal interaction
unassigned |
4
0 |
