EC Number |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
---|
3.4.24.56 | Alzheimer Disease |
10213160 |
Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques. |
causal interaction diagnostic usage ongoing research unassigned |
1 3 4 0 |
3.4.24.56 | Alzheimer Disease |
10786709 |
Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains. |
unassigned |
0 |
3.4.24.56 | Alzheimer Disease |
10833395 |
Functional human insulin-degrading enzyme can be expressed in bacteria. |
causal interaction unassigned |
3 0 |
3.4.24.56 | Alzheimer Disease |
11102481 |
Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques. |
therapeutic application unassigned |
4 0 |
3.4.24.56 | Alzheimer Disease |
11125142 |
Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. |
causal interaction unassigned |
3 0 |
3.4.24.56 | Alzheimer Disease |
11810277 |
Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. |
causal interaction unassigned |
4 0 |
3.4.24.56 | Alzheimer Disease |
12161276 |
Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease. |
causal interaction unassigned |
4 0 |
3.4.24.56 | Alzheimer Disease |
12507914 |
Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele. |
causal interaction unassigned |
2 0 |
3.4.24.56 | Alzheimer Disease |
12634421 |
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. |
causal interaction unassigned |
4 0 |
3.4.24.56 | Alzheimer Disease |
12732730 |
Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. |
causal interaction unassigned |
3 0 |