EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.24.42 | Arthritis |
8603731 |
Degradation of cartilage aggrecan by collagenase-3 (MMP-13). |
unassigned |
0 |
| 3.4.24.42 | Arthritis |
8941646 |
Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent. |
causal interaction
unassigned |
1
0 |
| 3.4.24.42 | Arthritis |
9536289 |
Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis. |
causal interaction
unassigned |
2
0 |
| 3.4.24.42 | Arthritis |
10415722 |
Aggrecanase. A target for the design of inhibitors of cartilage degradation. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 3.4.24.42 | Arthritis |
10640399 |
Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition of articular cartilage. |
causal interaction
unassigned |
1
0 |
| 3.4.24.42 | Arthritis |
10751421 |
Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4). |
unassigned |
0 |
| 3.4.24.42 | Arthritis |
11278243 |
TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5). |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 3.4.24.42 | Arthritis |
11801682 |
Expression and regulation of aggrecanase in arthritis: the role of TGF-beta. |
causal interaction
ongoing research
unassigned |
2
1
0 |
| 3.4.24.42 | Arthritis |
12020478 |
Aggrecanase-mediated cartilage degradation. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 3.4.24.42 | Arthritis |
12973442 |
Mechanisms of proteoglycan metabolism that lead to cartilage destruction in the pathogenesis of arthritis. |
causal interaction
unassigned |
4
0 |
