EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.1.3.76 | Adenocarcinoma of Lung |
21333374 |
Invasiveness and anchorage independent growth ability augmented by PTEN inactivation through the PI3K/AKT/NFkB pathway in lung cancer cells. |
causal interaction
diagnostic usage
ongoing research
unassigned |
1
1
1
0 |
| 3.1.3.76 | Alzheimer Disease |
26780512 |
PTEN recruitment controls synaptic and cognitive function in Alzheimer's models. |
causal interaction
unassigned |
4
0 |
| 3.1.3.76 | Alzheimer Disease |
32493451 |
The lipid phosphatase Synaptojanin 1 undergoes a significant alteration in expression and solubility and is associated with brain lesions in Alzheimer's disease. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 3.1.3.76 | Arthritis, Rheumatoid |
34288720 |
Inhibition of lipid phosphatase SHIP1 expands myeloid-derived suppressor cells and attenuates rheumatoid arthritis in mice. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
4
3 |
| 3.1.3.76 | Asthma |
30335467 |
Secretory Inositol Polyphosphate 4-Phosphatase Protects Against Airway Inflammation and Remodeling. |
causal interaction
ongoing research
unassigned |
1
2
0 |
| 3.1.3.76 | Breast Neoplasms |
11230179 |
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model. |
causal interaction
therapeutic application
unassigned |
1
1
0 |
| 3.1.3.76 | Breast Neoplasms |
24148769 |
BAG5 regulates PTEN stability in MCF-7 cell line. |
causal interaction
unassigned |
4
0 |
| 3.1.3.76 | Breast Neoplasms |
25605973 |
Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
1
3
0 |
| 3.1.3.76 | Breast Neoplasms |
33332075 |
Over expression of PTEN induces apoptosis and prevents cell proliferation in breast cancer cells. |
causal interaction
unassigned |
2
0 |
| 3.1.3.76 | Carcinogenesis |
10617573 |
Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. |
ongoing research
unassigned |
2
0 |
