EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   2.7.1.150 | 1-phosphatidylinositol-3-phosphate 5-kinase deficiency |
16835451 |
Transcription factor STE12alpha has distinct roles in morphogenesis, virulence, and ecological fitness of the primary pathogenic yeast Cryptococcus gattii. |
unassigned |
0 |
| 2.7.1.150 | 1-phosphatidylinositol-3-phosphate 5-kinase deficiency |
25619930 |
Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis. |
causal interaction
unassigned |
1
0 |
| 2.7.1.150 | 1-phosphatidylinositol-3-phosphate 5-kinase deficiency |
28533230 |
Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice. |
causal interaction
unassigned |
4
0 |
| 2.7.1.150 | 1-phosphatidylinositol-3-phosphate 5-kinase deficiency |
31427458 |
PIKfyve deficiency in myeloid cells impairs lysosomal homeostasis in macrophages and promotes systemic inflammation in mice. |
causal interaction
unassigned |
4
0 |
| 2.7.1.150 | 1-phosphatidylinositol-3-phosphate 5-kinase deficiency |
31824437 |
Cell-Wall-Degrading Enzymes Required for Virulence in the Host Selective Toxin-Producing Necrotroph Alternaria alternata of Citrus. |
unassigned |
0 |
| 2.7.1.150 | Acquired Immunodeficiency Syndrome |
32079455 |
Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block. |
ongoing research
unassigned |
2
0 |
| 2.7.1.150 | Adenocarcinoma |
33685990 |
Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells. |
causal interaction
ongoing research
therapeutic application
unassigned |
3
3
3
0 |
| 2.7.1.150 | Albuminuria |
30066585 |
Nephron specific knockin of the PIKfyve binding deficient Vac14L156R mutant results in albuminuria and mesangial expansion. |
causal interaction
therapeutic application
unassigned |
2
1
0 |
| 2.7.1.150 | Alzheimer Disease |
26216398 |
APP controls the formation of PI(3,5)P(2) vesicles through its binding of the PIKfyve complex. |
ongoing research
therapeutic application
unassigned |
1
1
0 |
| 2.7.1.150 | Alzheimer Disease |
26862204 |
The amyloid precursor protein (APP) binds the PIKfyve complex and modulates its function. |
causal interaction
therapeutic application
unassigned |
2
1
0 |
