EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   2.4.1.9 | Asthma |
29703864 |
Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation. |
causal interaction
ongoing research
therapeutic application
unassigned |
3
2
3
0 |
| 2.4.1.9 | Blindness |
29932012 |
Choroideremia: molecular mechanisms and development of AAV gene therapy. |
causal interaction
ongoing research
therapeutic application
unassigned |
1
2
1
0 |
| 2.4.1.9 | Bone Resorption |
12733981 |
Protein farnesyltransferase inhibitors. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 2.4.1.9 | Breast Neoplasms |
14695209 |
Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
4
4
0 |
| 2.4.1.9 | Breast Neoplasms |
16769985 |
Targeted inhibition of farnesyltransferase in locally advanced breast cancer: a phase I and II trial of tipifarnib plus dose-dense doxorubicin and cyclophosphamide. |
diagnostic usage
ongoing research
therapeutic application
unassigned |
3
3
4
0 |
| 2.4.1.9 | Breast Neoplasms |
19351752 |
Phase II trial of tipifarnib plus neoadjuvant doxorubicin-cyclophosphamide in patients with clinical stage IIB-IIIC breast cancer. |
unassigned |
0 |
| 2.4.1.9 | Carcinogenesis |
16925112 |
In vitro and in vivo evaluation of two rational-designed nonpeptidic farnesyltransferase inhibitors on HT29 human colon cancer cell lines. |
causal interaction
ongoing research
therapeutic application
unassigned |
3
3
4
0 |
| 2.4.1.9 | Carcinogenesis |
20653956 |
A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics. |
ongoing research
unassigned |
2
0 |
| 2.4.1.9 | Carcinoma |
8607844 |
Farnesyltransferase activity and mRNA expression in human skin basal cell carcinomas. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
4
1 |
| 2.4.1.9 | Carcinoma |
8876671 |
Protection against malignant conversion in SENCAR mouse skin by all trans retinoic acid: inhibition of the ras p21-processing enzyme farnesyltransferase and Ha-ras p21 membrane localization. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
3
2
2 |
