EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   2.3.1.B41 | Acne Vulgaris |
30105859 |
Sirtuin6 inhibits c-triggered inflammation through TLR4 abrogation regulated by ROS and TRPV1/CGRP. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 2.3.1.B41 | Acute Kidney Injury |
29373150 |
Overexpressed SIRT6 attenuates cisplatin-induced acute kidney injury by inhibiting ERK1/2 signaling. |
causal interaction
unassigned |
4
0 |
| 2.3.1.B41 | Acute Kidney Injury |
30700227 |
Sirtuin 6 overexpression relieves sepsis-induced acute kidney injury by promoting autophagy. |
causal interaction
ongoing research
unassigned |
2
3
0 |
| 2.3.1.B41 | Acute Lung Injury |
30784091 |
Sirtuin 6 mitigated LPS-induced human umbilical vein endothelial cells inflammatory responses through modulating nuclear factor erythroid 2-related factor 2. |
ongoing research
unassigned |
2
0 |
| 2.3.1.B41 | Adenocarcinoma |
27180906 |
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
1
1
3 |
| 2.3.1.B41 | Adenocarcinoma |
32283646 |
Structural Insight into the Interactions between Structurally Similar Inhibitors and SIRT6. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 2.3.1.B41 | Adenocarcinoma |
32787077 |
Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 2.3.1.B41 | Adenocarcinoma of Lung |
26180037 |
SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
4
4
4 |
| 2.3.1.B41 | Adenocarcinoma of Lung |
31399301 |
SIRT6-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal transition. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
3
3
1
0 |
| 2.3.1.B41 | Adenoviridae Infections |
30670969 |
SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
