EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
    2.3.1.50 | alpha-galactosidase deficiency |
18467744 |
Reduction of plasma glycosphingolipid levels has no impact on atherosclerosis in apolipoprotein E-null mice. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 2.3.1.50 | Alzheimer Disease |
21994399 |
MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid ?, novel targets in sporadic Alzheimer's disease. |
causal interaction
unassigned |
4
0 |
| 2.3.1.50 | Alzheimer Disease |
23528227 |
Inhibition of serine palmitoyltransferase reduces A? and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease. |
causal interaction
ongoing research
therapeutic application
unassigned |
3
1
4
0 |
| 2.3.1.50 | Amyotrophic Lateral Sclerosis |
34325980 |
Towards personalized medicine for amyotrophic lateral sclerosis. |
ongoing research
unassigned |
3
0 |
| 2.3.1.50 | Amyotrophic Lateral Sclerosis |
34459874 |
Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis. |
ongoing research
unassigned |
1
0 |
| 2.3.1.50 | Ataxia |
12207934 |
Exclusion of serine palmitoyltransferase long chain base subunit 2 (SPTLC2) as a common cause for hereditary sensory neuropathy. |
causal interaction
unassigned |
3
0 |
| 2.3.1.50 | Atherosclerosis |
3093620 |
Enzymology of long-chain base synthesis by aorta: induction of serine palmitoyltransferase activity in rabbit aorta during atherogenesis. |
ongoing research
therapeutic application
unassigned |
3
1
0 |
| 2.3.1.50 | Atherosclerosis |
3430071 |
Inhibition of serine palmitoyltransferase activity in rabbit aorta by L-cycloserine. |
therapeutic application
unassigned |
3
0 |
| 2.3.1.50 | Atherosclerosis |
17239824 |
Inhibition of atherosclerosis by the serine palmitoyl transferase inhibitor myriocin is associated with reduced plasma glycosphingolipid concentration. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
3
3
0 |
| 2.3.1.50 | Atherosclerosis |
17978313 |
Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice. |
ongoing research
therapeutic application
unassigned |
2
2
0 |
