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EC Number Disease PubMed ID Title of Publication Category Confidence Level
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21Precursor Cell Lymphoblastic Leukemia-Lymphoma 17392819 Increased resistance to a farnesyltransferase inhibitor by N-cadherin expression in Bcr/Abl-P190 lymphoblastic leukemia cells. causal interaction
ongoing research
therapeutic application
unassigned
1
4
1
0
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21Precursor Cell Lymphoblastic Leukemia-Lymphoma 22399601 Farnesyltransferase inhibitors: molecular evidence of therapeutic efficacy in acute lymphoblastic leukemia through cyclin d1 inhibition. causal interaction
therapeutic application
unassigned
3
4
0
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21Precursor Cell Lymphoblastic Leukemia-Lymphoma 22934254 Environment-mediated drug resistance in Bcr/Abl-positive acute lymphoblastic leukemia. ongoing research
therapeutic application
unassigned
3
4
0
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21Primary Myelofibrosis 12750696 In vitro antiproliferative activity of the farnesyltransferase inhibitor R115777 in hematopoietic progenitors from patients with myelofibrosis with myeloid metaplasia. causal interaction
ongoing research
therapeutic application
unassigned
3
2
3
0
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21Progeria 16126733 Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition. causal interaction
unassigned
2
0
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21Progeria 16862216 A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation. causal interaction
ongoing research
therapeutic application
unassigned
1
4
4
0
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21Progeria 18082640 Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation. causal interaction
therapeutic application
unassigned
1
4
0
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21Progeria 18331619 Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors. causal interaction
therapeutic application
unassigned
1
1
0
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21Progeria 18838683 A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model. therapeutic application
unassigned
4
0
Show all pathways known for 2.5.1.21Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.21Progeria 20074076 Progeria, the nucleolus and farnesyltransferase inhibitors. therapeutic application
unassigned
4
0
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