EC Number |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
---|
3.1.13.2 | -999 |
- |
more |
- |
677430 |
3.1.13.2 | -999 |
- |
more |
IC50 more than 18 microM for hyemaloside B |
693714 |
3.1.13.2 | -999 |
- |
more |
IC50 value is higher than 96.00 microM for 7-bromo-2-hydroxyisoquinoline-1,3(2H,4H)-dione. IC50 value is higher than 80.0 microM for N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)pentanamide, for 2-hydroxy-7-phenylisoquinoline-1,3(2H,4H)-dione, and for N-(2-hydroxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-7-yl)-2-phenylacetamide. pH 8.0, 37°C |
693575 |
3.1.13.2 | -999 |
- |
more |
IC50 values of different oligonucleotides with structural characters of hairpins and dumbbells: 0.000500 mM for oligonucleotide with 35 base pairs based on the G-quartet motif, 0.0258 mM for 1R4RR4, 0.0262 mM for 2R4RR4, 0.0693 mM for 3R4RR4, 0.0078 mM for 6R6RR6, 0.0297 mM for 7R6RR6, 0.0404 mM for 8nicked dumbbell, and 0.0033 mM for 9ligared dumbbell. IC50 value is much higher than 100 microM for 4D4RD4 and 5R4D4R. [(4-chlorophenyl)hydrazono] propanedioic acid shows an IC50 value of 3 microM against polymerase-independent RNase H activity. Its activity against HIV-1 RNase H in vivo and toxicity in cell culture or in vivo still need to be investigated. IC50 0.0013 mM for 3,7-dihydroxy-tropolone, monosubstituted, and 0.0047 mM for 3,7-dihydroxy-tropolone, unsubstituted |
694054 |
3.1.13.2 | -999 |
- |
more |
inhibition of mutant enzymes by DHBNH and antiviral activity, overview |
677282 |
3.1.13.2 | -999 |
- |
more |
the IC50 values for 3-[(8Z)-pentadec-8-en-1-yl]phenol, 3-[(10Z)-heptadec-10-en-1-yl]phenol, 3-tridecylphenol, 3-pentadecylphenol, 5-[(8Z)-pentadec-8-en-1-yl]benzene-1,3-diol, and 5-tridecylbenzene-1,3-diol are above 200 microM |
694787 |
3.1.13.2 | -999 |
- |
more |
Y5014-(phenylcarbonyl)-L-Phe mutant, the IC50 value is above 300 microM |
693687 |
3.1.13.2 | 0.0000045 |
- |
efavirenz |
pH 8.0, 22°C, wild-type enzyme |
671783 |
3.1.13.2 | 0.0000076 |
- |
GW8248 |
pH 8.0, 22°C, wild-type enzyme |
671783 |
3.1.13.2 | 0.0000084 |
- |
capravirine |
pH 8.0, 22°C, wild-type enzyme |
671783 |