EC Number |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
---|
2.7.1.153 | -999 |
- |
more |
IC50 value of inhibitor 4-[4-(morpholin-4-yl)-5a,6-dihydro[1]benzofuro[3,2-d]pyrimidin-2-yl]phenol is 2 nmol/l against recombinant isoform p110alpha, 3 nmol/l against recombinant isoform p110beta, 3 nmol/l against recombinant isoform p110delta, 15 nmol/l against recombinant isoform p110agamma |
691604 |
2.7.1.153 | 0.00000022 |
- |
6-amino-2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-4-methoxy-1H-benzimidazole |
isoform p110alpha, pH not specified in the publication, temperature not specified in the publication |
722917 |
2.7.1.153 | 0.0000003 |
- |
2-methyl-3-[2-methyl-3-(trifluoromethyl)benzyl]-5-(2methylmorpholin-4-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one |
beta isoform, pH not specified in the publication, temperature not specified in the publication |
721812 |
2.7.1.153 | 0.00000038 |
- |
6-amino-2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-4-methoxy-1H-benzimidazole |
isoform p110delta, pH not specified in the publication, temperature not specified in the publication |
722917 |
2.7.1.153 | 0.0000004 |
- |
2-(methylsulfanyl)-3-[2-methyl-3-(trifluoromethyl)benzyl]-5-(morpholin-4-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one |
beta isoform, pH not specified in the publication, temperature not specified in the publication |
721812 |
2.7.1.153 | 0.0000006 |
- |
2-methyl-3-[2-methyl-3-(trifluoromethyl)benzyl]-5-(morpholin-4-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one |
beta isoform, pH not specified in the publication, temperature not specified in the publication |
721812 |
2.7.1.153 | 0.0000009 |
- |
N-[2-(dimethylamino)ethyl]-N-methyl-4-[([4-[4-morpholin-4-yl-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d ]pyrimidin-2-yl]phenyl]carbamoyl)amino]benzamide |
pH not specified in the publication, temperature not specified in the publication |
722910 |
2.7.1.153 | 0.000001 |
- |
1-[2-methyl-3-(trifluoromethyl)benzyl]-2-methyl-7-(morpholin-4-yl)-6,7-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one |
pH not specified in the publication, temperature not specified in the publication |
721811 |
2.7.1.153 | 0.000001 |
- |
1-[2-methyl-3-(trifluoromethyl)benzyl]-7-[(2R)-2-methylmorpholin-2-yl]-6,7-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one |
pH not specified in the publication, temperature not specified in the publication |
721811 |
2.7.1.153 | 0.000001 |
- |
4-[2-[(6-methoxypyridin-3-yl)amino]-5-phenylpyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine |
isoform delta, pH not specified in the publication, temperature not specified in the publication |
722922 |