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EC Number	IC50 Value	IC50 Value Maximum	Inhibitor	Commentary	Reference
2.3.1.32	-999	-	more	10, 25, 50 microM inhibit FLAG-tagged recombinant PCAF in vitro with an IC50 beyond 50 microM with purified human HeLa core histone as substrate	704529
2.3.1.32	-999	-	more	Hep-G2 hepatocarcinoma cells: with 5 microM plumbagin 50% reduction of histone H3 acetylation, with 25 microM 90% reduction, significant overall acetylation status of histones, prominent reduction in H3 and H4, immunofluorescence analysis (anti-acetylated histone H3 polyclonal antibodies) of HeLa cells (treated with deacetylase inhibitors to induce histone acetylation) confirm the inhibitory effect of plumbagin with 5 microM inhibitor, with 25 microM almost complete reduction in acetylation level	704529
2.3.1.32	-999	-	more	significant decrease of histone acetylation in plumbagin treated mouse liver in vivo 6 h after intraperitoneal injection of 25 mg plumbagin/kg body mass	704529
2.3.1.32	0.002	-	Plumbagin	recombinant minimal HAT domain of p300	704529
2.3.1.32	0.02	-	Plumbagin	recombinant full-length p300	704529

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Release 2023.1 (January 2023)