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EC Number Crystallization (Commentary)
Show all pathways known for 4.2.1.18Display the word mapDisplay the reaction diagram Show all sequences 4.2.1.18AUH is crystallized with a long RNA containing 24 repeats of the AUUU motif. AUH structure is determined as an asymmetric dimer of trimers with a kink in the alignment of the trimer axes, resulting in the formation of two clefts with significantly different sizes
Show all pathways known for 4.2.1.18Display the word mapDisplay the reaction diagram Show all sequences 4.2.1.18structures refined to 2.05 and 1.1 A, in the apo form and bound to coenzyme A, respectively. The dehydration of 3-hydroxy-3-methylglutaryl CoA to 3-methylglutaconyl CoA involves Glu112 and Glu132 and likely employs the typical crotonase acid-base mechanism. Residues Tyr231 and Arg69 are key players in positioning the substrate to enable catalysis
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