EC Number |
Ki Value [mM] |
Ki Value maximum [mM] |
Inhibitor |
Reference |
---|
2.4.2.12 | -999 |
- |
ATP |
> 4 mM, inhibition of NMN synthesis by phosphorylated NAMPT |
690900 |
2.4.2.12 | -999 |
- |
FK866 |
10 +/-1 pM, with respect to alpha-D-5-phosphoribosyl 1-diphosphate (PRPP), in presence of 2.5 mM ATP, KM/Ki = 63000, 200 microM PRPP, 100 nM nicotinamide, 2.2 nM NAMPT, 15 min |
690900 |
2.4.2.12 | -999 |
- |
FK866 |
150 +/-18 pM, with respect to nicotinamide, in presence of 2.5 mM ATP, KM/Ki = 33, 200 microM PRPP, 100 nM nicotinamide, 2.2 nM NAMPT, 15 min |
690900 |
2.4.2.12 | -999 |
- |
FK866 |
5000 +/-500 pM, with respect to nicotinamide, in absence of ATP, KM/Ki = 171, 100 microM PRPP, 1 microM nicotinamide, 88 nM NAMPT, 15 min |
690900 |
2.4.2.12 | -999 |
- |
FK866 |
730 +/-75 pM, with respect to alpha-D-5-phosphoribosyl 1-diphosphate (PRPP), in absence of ATP, KM/Ki = 9863, 100 microM PRPP, 1 microM nicotinamide, 88 nM NAMPT, 15 min |
690900 |
2.4.2.12 | -999 |
- |
NAD+ |
> 100 microM, with respect to nicotinamide, in absence of ATP |
690900 |
2.4.2.12 | -999 |
- |
NADH |
> 100 microM, with respect to nicotinamide, in absence of ATP |
690900 |
2.4.2.12 | 0.000001 |
- |
N-[4-(1-benzoylpiperidin-4-yl)phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide |
pH and temperature not specified in the publication |
758914 |
2.4.2.12 | 0.0000015 |
- |
N-(4-[1-[2-methyl-2-(4-methylpiperazin-1-yl)propanoyl]piperidin-4-yl]phenyl)-1,3-dihydro-2H-isoindole-2-carboxamide |
pH and temperature not specified in the publication |
758914 |
2.4.2.12 | 0.0000016 |
- |
N-[4-(1-benzoylpiperidin-4-yl)butyl]-1,3-dihydro-2H-isoindole-2-carboxamide |
pH and temperature not specified in the publication |
758914 |