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EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Reference
1.3.1.22
-999
-
more
inhibition kinetics
655182
1.3.1.22
-999
-
more
isozyme-specific IC50-values of diverse inhibitors, overview
656656
1.3.1.22
-999
-
more
the majority of the enzyme variants result in a reduction of the apparent Ki for both finasteride and dutasteride from 10 min to the 30 min reaction like the wild-type enzyme, but several variants result in an increase of the apparent Ki for each inhibitor or no significant change between the 10 min and 30 min reactions, thus exhibiting time independent inhibition
675475
1.3.1.22
0.0000003
-
acylate episteride
iosenzyme 2
396219
1.3.1.22
0.0000005
-
acylate episteride
iosenzyme 2
396219
1.3.1.22
0.000001
-
finasteride
iosenzyme 2
396219
1.3.1.22
0.000002
-
4-methyl-azasteroid
iosenzyme 2
396219
1.3.1.22
0.0000027
-
8-chloro-4-methyl-1,2,5,6-tetrahydro-3H-pyrido[1,2-a]quinolin-3-one
isoform I
656656
1.3.1.22
0.000003
-
4-methyl-azasteroid
iosenzyme 1
396219
1.3.1.22
0.000003
-
4-methyl-azasteroid
iosenzyme 2
396219
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