EC Number   |
Cofactor |
Reference |
|---|
    4.1.1.22 | more |
HDC uses a covalently bound pyruvoyl moiety as cofactor |
653849 |
| 4.1.1.22 | more |
pyruvoyl-residue at the NH2-terminus |
692670 |
| 4.1.1.22 | pyridoxal 5'-phosphate |
- |
4153, 4154, 650807, 651162, 677857, 680148, 680165, 680301, 680763, 682308, 687047, 690301, 690319, 690487, 690553, 690666, 690778, 691489, 691549, 691585, 692084, 692565, 692606, 692670, 692805, 692809, 693044, 693426, 693469, 693822, 693829, 694385, 694402, 714942, 715728, 716876, 747573, 748712, 748845, 749421 |
| 4.1.1.22 | pyridoxal 5'-phosphate |
activates, but does not influence the enzyme expression level |
679896 |
| 4.1.1.22 | pyridoxal 5'-phosphate |
after dialysis for 48 h against buffer containing 1 mM semicarbazide, about 50% loss of activity, full recovery by adding pyridoxal 5'-phosphate. Km: 0.001 mM |
4144 |
| 4.1.1.22 | pyridoxal 5'-phosphate |
cofactor is located in the large domain. The pyridine ring of pyridoxal 5'-phosphate is sandwiched between the methyl group of Ala275 and the imidazole ring of His194 |
727920 |
| 4.1.1.22 | pyridoxal 5'-phosphate |
contains 1 mol of pyridoxal 5'-phosphate per mol of subunit |
4154, 4159 |
| 4.1.1.22 | pyridoxal 5'-phosphate |
dependent on |
663937, 679733, 680149 |
| 4.1.1.22 | pyridoxal 5'-phosphate |
dependent on, binding structure involving a Schiff base, overview |
680933 |
| 4.1.1.22 | pyridoxal 5'-phosphate |
Km for pyridoxal 5'-phosphate with soluble enzyme: 0.00243 mM. Km for pyridoxal 5'-phosphate with membrane-bound enzyme: 0.00296 mM. Km for pyridoxal 5'-phosphate with solubilized membrane-bound enzyme: 0.00286 mM |
4160 |
