EC Number |
Cofactor |
Reference |
---|
2.7.11.2 | ATP |
- |
660805, 660923, 661046, 661094, 661812, 661961, 661963, 662151, 662397, 662537, 662948, 671870, 672273, 672978, 673007, 673647, 674640, 674730, 677167, 698954, 705630, 721523, 721971, 722148, 722788, 723006 |
2.7.11.2 | ATP |
binding kinetics, ATP or ADP plus pyruvate at low concentration of about 0.1 mM cause PDHK2 dimer to associate to a tetramer. These changes make major contributions to synergistic inhibition of PDHK2 activity by ADP and pyruvate, overview |
674544 |
2.7.11.2 | ATP |
binding site structure, involves Gly317 and Tyr320, and K+ ions |
661219 |
2.7.11.2 | ATP |
binding structure with isozyme PDK4, detailed overview |
721159 |
2.7.11.2 | ATP |
causes a decrease in PDHK2 affinity for the L2 domain |
660995 |
2.7.11.2 | ATP |
dependent on |
348935, 640580, 642132, 642133, 642134, 642135, 642136, 642137, 642138, 642139, 642141, 642142, 642143, 642144, 642145, 642146, 642148, 642149, 642150, 642151, 642152, 642153, 642154, 642155, 642156, 642157, 642158, 642159, 642160, 642162, 642163, 642164, 642165, 94884, 94893 |
2.7.11.2 | ATP |
L2 binding increases affinities for both ADP and ATP |
661592 |
2.7.11.2 | ATP |
ordered reaction mechanism with ATP |
661094 |
2.7.11.2 | ATP |
the ATP-binding loop in one PDHK3 subunit adopts an open conformation, implying that the nucleotide loading into the active site is mediated by the inactive pre-insertion binding mode |
675449 |
2.7.11.2 | ATPgammaS |
dissociation constants as ATP in binding to PDK3 |
661592 |