EC Number |
Cofactor |
Reference |
---|
2.7.11.17 | 3-phosphoinositide |
enzyme is dependent on |
395498 |
2.7.11.17 | ATP |
- |
490796, 490797, 490801, 663862, 664278, 664472, 664506, 664537, 664641, 664750, 664865, 664928, 664935, 665484, 665508, 665533, 665541, 665624, 665648, 665662, 665701, 665759, 666110, 666114, 666119, 666127, 666130, 666132, 666139, 666401, 666454, 666459, 666623, 666707, 671266, 671799, 672384, 672850, 672940, 672941, 674557, 675034, 675065, 675526, 675548, 675969, 676041, 676174, 676849, 690363, 690372, 690822, 690926, 691539, 691560, 691612, 691673, 691719, 691837, 692226, 692227, 692345, 693128, 693204, 693725, 693760, 693764, 693768, 694154, 694370, 694372, 694382, 694396, 694887, 702957, 703089, 703406, 705313, 705318, 705904, 740003, 740270, 740328, 740718, 740886, 741158, 741420 |
2.7.11.17 | ATP |
dependent on |
666324 |
2.7.11.17 | ATP |
the ATP-binding site is influenced by the autoinhibitory conformation |
490800 |
2.7.11.17 | Calmodulin |
a ubiquitous Ca2+-sensing protein called calmodulin (CaM), which contains four EF-hand Ca2+-binding motifs, undergoes conformational change upon Ca2+-binding, and the resulting Ca2+/CaM complex regulates a number of effector proteins including Ca2+/CaM-dependent protein kinases (Ca2+/CaMKs) |
739960 |
2.7.11.17 | Calmodulin |
after autophosphorylation, the enzyme is active in the absence of Ca2+/calmodulin and even in the presence of EGTA |
640689 |
2.7.11.17 | Calmodulin |
binding required for activity |
490796, 490797, 490800, 490801 |
2.7.11.17 | Calmodulin |
calcium-calmodulin dependent signalling via Ca2+ leads to activation of CAMKIV autoinhibition |
740003 |
2.7.11.17 | Calmodulin |
CaV2.1(18481964) contains an IQ-like motif as part of a bipartite regulatory site that is important for CaM-induced facilitation and inactivation of CaV2.1 channels. IQ-like motifs bind CaM. CaM is not required for CaMKII binding to Ca2+channels |
740718 |
2.7.11.17 | Calmodulin |
dependent on |
690363, 690372, 690822, 690926, 691539, 691560, 691612, 691668, 691673, 691719, 691837, 691978, 692226, 692227, 692345, 693128, 693725, 693760, 693764, 693767, 694154, 694370, 694372, 694382, 694396, 694403, 694887 |