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EC Number Cofactor Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.2.4.4CoA - 349040, 349047, 349048, 349049, 349050, 349051, 349052, 349053, 349054, 349055, 349056, 349057, 349058, 349059, 349060, 349063, 349064, 349065, 349067, 349068, 349069, 349070, 349071, 349072, 349073, 349074, 349075, 349076, 349077, 349078, 349079, 349080, 349082, 349083, 349084, 349085, 349086, 349088, 349089, 349090, 349091, 587061, 710845, 713078, 725430, 741029, 94884
Display the word mapDisplay the reaction diagram Show all sequences 1.2.4.4CoA extraordinarily tightly bound 349081
Display the word mapDisplay the reaction diagram Show all sequences 1.2.4.4CoA Km: 0.0071 mM in the reaction with 4-methyl-2-oxopentanoate, Km: 0.009 mM in the reaction with 3-methyl-2-oxobutanoate, Km: 0.007 in the reaction with DL-3-methyl-2-oxopentanoate 349062
Display the word mapDisplay the reaction diagram Show all sequences 1.2.4.4CoA Km: 0.064 mM 349061
Display the word mapDisplay the reaction diagram Show all sequences 1.2.4.4CoA the multienzyme complex catalyzes a thiamine diphosphate- and Mg2+-dependent oxidative decarboxylation of branched-chain keto acids with the formation of branched-chain acyl-CoA and reduction of NAD+ to NADH: R1R2CHCOCOOH + NAD+ + CoASH = R1R2CHCO-S-CoA + NADH + CO2, component E1 (EC 1.2.4.4, branched-chain keto acid dehydrogenase), component E2 (no EC number, branched-chain acyltransferase), component E3 (EC 1.8.1.4, dihydrolipoamide dehydrogenase), partial reactions catalyzed by the multienzyme complex: 1. R1R2CHCOCOOH + E1-(thiamine diphosphate) = E1-(thiamine diphosphate)-COHCHR1R2 + CO2, 2. E1-(thiamine diphosphate)-COHCHR1R2 + lipoyl-E2 = R1R2CHCO-SCoA + dihydrolipoyl-E2, 4. dihydrolipoyl-E2 + NAD+ = lipoyl-E2 + NADH 349045
Display the word mapDisplay the reaction diagram Show all sequences 1.2.4.4FAD - 741029
Display the word mapDisplay the reaction diagram Show all sequences 1.2.4.4NAD+ - 349040, 349047, 349048, 349049, 349050, 349051, 349052, 349053, 349054, 349055, 349056, 349057, 349058, 349059, 349060, 349061, 349063, 349064, 349065, 349067, 349068, 349069, 349070, 349071, 349072, 349073, 349074, 349075, 349076, 349077, 349078, 349079, 349080, 349081, 349082, 349083, 349084, 349085, 349086, 349088, 349089, 349090, 349091, 587061, 686676, 686828, 710845, 713078, 723788, 725430, 739536, 741029, 741079, 94884
Display the word mapDisplay the reaction diagram Show all sequences 1.2.4.4NAD+ Km: 0.109 mM in the reaction with 4-methyl-2-oxopentanoate, Km: 0.126 mM in the reaction with 3-methyl-2-oxobutanoate, Km: 0.101 mM in the reaction with DL-3-methyl-2-oxobutanoate 349062
Display the word mapDisplay the reaction diagram Show all sequences 1.2.4.4NAD+ the multienzyme complex catalyzes a thiamine diphosphate- and Mg2+-dependent oxidative decarboxylation of branched-chain keto acids with the formation of branched-chain acyl-CoA and reduction of NAD+ to NADH: R1R2CHCOCOOH + NAD+ + CoASH = R1R2CHCO-S-CoA + NADH + CO2, component E1 (EC 1.2.4.4, branched-chain keto acid dehydrogenase), component E2 (no EC number, branched-chain acyltransferase), component E3 (EC 1.8.1.4, dihydrolipoamide dehydrogenase), partial reactions catalyzed by the multienzyme complex: 1. R1R2CHCOCOOH + E1-(thiamine diphosphate) = E1-(thiamine diphosphate)-COHCHR1R2 + CO2, 2. E1-(thiamine diphosphate)-COHCHR1R2 + lipoyl-E2 = R1R2CHCO-SCoA + dihydrolipoyl-E2, 4. dihydrolipoyl-E2 + NAD+ = lipoyl-E2 + NADH 349045
Display the word mapDisplay the reaction diagram Show all sequences 1.2.4.4thiamine diphosphate - 677159, 741029
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