EC Number |
Cofactor |
Reference |
---|
1.1.1.82 | NAD+ |
NADP+ is the preferred cofactor compared to NAD+ with substrate (S)-malate, while NAD+ is preferred with substrate tartrate. Ala at position 53 is responsible for coenzyme specificity, and the next residue, Arg, is important for NADP+ binding, structural analysis and comparison |
696461 |
1.1.1.82 | NADP+ |
- |
739249, 740926, 741200, 762295, 762354 |
1.1.1.82 | NADP+ |
NADP+ binds to Ser9, Arg34, His36, Ser37, Ile121, Asn123, and Glu219 |
740926 |
1.1.1.82 | NADP+ |
NADP+ is the preferred cofactor compared to NAD+ with substrate (S)-malate, while NAD+ is preferred with substrate tartrate. Ala at position 53 is responsible for coenzyme specificity, and the next residue, Arg, is important for NADP+ binding, structural analysis and comparison |
696461 |
1.1.1.82 | NADPH |
- |
739249, 740926, 741200, 762295, 762354 |
1.1.1.82 | NADPH |
cofactor |
287384, 287385, 287386, 287387 |
1.1.1.82 | NADPH |
nicotinamide binds to the hydrophobic cleft of MDH from Thermus flavus composed of Leu40, Ile42, Ile107, Thr9, Gly10, Gly87, and Ala88 |
740926 |