EC Number   |
Cofactor |
Reference |
|---|
    1.1.1.41 | more |
in the presence of Mn2+ and Mg2+, OtIDH displays 42fold and 51fold preference for NAD+ over NADP+, respectively |
740425 |
| 1.1.1.41 | more |
the enzyme is also active with NADP+ and NADPH, cf. EC 1.1.1.42 |
723607 |
| 1.1.1.41 | NAD+ |
- |
286749, 286750, 286751, 286752, 286753, 286754, 286755, 286756, 286757, 286758, 286759, 286760, 286761, 286762, 286763, 286764, 286765, 286766, 286767, 286768, 286769, 286770, 286771, 286772, 286773, 286774, 286775, 286776, 286777, 654783, 663920, 667647, 669465, 669477, 670544, 670547, 670847, 695342, 696358, 700359, 712440, 713076, 713380, 721433, 723607, 740114, 741458, 760834, 761311, 761502, 762238, 762313, 762407, 762437, 762451 |
| 1.1.1.41 | NAD+ |
1 mM |
660907 |
| 1.1.1.41 | NAD+ |
dependent on |
654652, 657111, 721381 |
| 1.1.1.41 | NAD+ |
dependent on, one NAD+ site per enzyme tetramer, two functional NAD+ binding sites in the wild-type enzyme |
721650 |
| 1.1.1.41 | NAD+ |
highly preferred cofactor, 78fold higher activity than with NADP+ |
655607 |
| 1.1.1.41 | NAD+ |
specific for |
654843, 654914, 656052, 656189, 740425, 741407 |
| 1.1.1.41 | NAD+ |
specific for NAD+ |
684713 |
| 1.1.1.41 | NAD+ |
specific for, binding site at subunit IDH2 |
656118 |
