EC Number |
Cofactor |
Reference |
---|
1.1.1.27 | 3-acetyl-pyridine adenine dinucleotide |
i.e. APAD+, 3-acetylpyridine adenine dinucleotide, analogue of NAD+ |
740541 |
1.1.1.27 | 3-acetylpyridine adenine dinucleotide |
alternative coenzyme |
286471 |
1.1.1.27 | 3-acetylpyridine adenine dinucleotide |
assay is based on reduction of 3-acetyl pyridine adenine dinucleotide that is specific for PfLDH, which allows the distinction of PfLDH from that of the host erythrocyte |
668525 |
1.1.1.27 | 3-acetylpyridine adenine dinucleotide |
wild-type and S163 L mutant protein bind 3-acetylpyridine adenine dinucleotide more tightly than they bind NADH |
286458 |
1.1.1.27 | beta-NAD+ |
- |
680322 |
1.1.1.27 | beta-NADH |
- |
680322 |
1.1.1.27 | Fe-S center |
- |
761650 |
1.1.1.27 | FMN |
contains non-covalently bound FMN as prosthetic group |
286450 |
1.1.1.27 | more |
Cryptosporidium parvum lactate dehydrogenase prefers the acetylpyridine analogue of NADH as a cofactor. NADH/APADH and substrate binding site structures, overview. replacement of the conserved serine residue by Met163 in CpLDH allows a better packing environment for the acetyl of APAD+ |
740541 |
1.1.1.27 | more |
the enzyme also utilizes both NAD(H) and NADP(H) |
684561 |