EC Number   |
Cofactor |
Reference |
|---|
   1.1.1.146 | NAD+ |
- |
285948, 725812, 740915, 760956, 761000 |
| 1.1.1.146 | NAD+ |
11beta-HSD2 |
667962 |
| 1.1.1.146 | NAD+ |
20 times lower affinity than for NADP+ |
285958 |
| 1.1.1.146 | NAD+ |
NADP+ is the preferred cofactor, low activity with NAD+ |
285967 |
| 1.1.1.146 | NADH |
- |
285948 |
| 1.1.1.146 | NADH |
NADPH is the preferred cofactor, low activity with NADH |
285967 |
| 1.1.1.146 | NADH |
no substrate affinity |
285958 |
| 1.1.1.146 | NADP+ |
- |
285945, 285946, 285947, 285952, 285956, 285958, 285959, 285960, 285961, 285962, 285967, 654889, 656356, 667148, 667152, 668126, 669419, 670261, 670264, 688766, 690401, 691275, 692338, 693544, 693886, 694805, 695090, 695146, 696570, 697737, 698026, 699713, 699841, 699842, 700121, 700178, 700179, 700181, 701241, 711471, 711737, 712257, 713232, 740024, 740132, 740146, 740149, 740151, 740375, 740803, 740917, 741444, 761543 |
| 1.1.1.146 | NADP+ |
11beta-hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP+ |
700180 |
| 1.1.1.146 | NADP+ |
20 times higher affinity than for NAD+ |
285958 |
