EC Number   |
Cofactor |
Reference |
|---|
   1.1.1.12 | more |
no activity with NADP+ |
710970, 711121 |
| 1.1.1.12 | more |
no activity with NADP+/NADPH |
760394 |
| 1.1.1.12 | NAD+ |
- |
246416, 668063, 695737, 696988, 710970, 721913, 739939, 740145, 740218, 740772, 760394, 761551, 762388 |
| 1.1.1.12 | NAD+ |
cofactor NAD+ binding domain involving residues Gly202, ILeu204, Gly205, Cys273, Arg229 and Val298, molecular docking studies |
712797 |
| 1.1.1.12 | NAD+ |
electron density corresponding to the bound NAD+ cofactor is observed within the smaller nucleotide-binding domain, along a crevice between the two domains. The adenine ring is nestled in a shallow pocket created by numerous hydrophobic residues, including Ile212, Val232, Thr260, and Val262. The nicotinamide is adjacent to the catalytic zinc ion, where it is poised for hydride transfer to the C2 atom of the substrate |
712767 |
| 1.1.1.12 | NAD+ |
no activities when NADP+ as cofactor |
669541 |
| 1.1.1.12 | NAD+ |
preferred cofactor |
738728 |
| 1.1.1.12 | NAD+ |
specific for NAD+ |
711121 |
| 1.1.1.12 | NAD+ |
strong preference for NAD+ |
684627 |
| 1.1.1.12 | NADH |
- |
246416, 668063, 684627, 760394, 761551, 762388 |
