   3.4.21.43 | More |
C2 is a glycosylated modular protein consisting of three domains, C2a is the catalytic fragment of classical pathway C3 and C5 convertase of human complement, formation of the convertases requires the Mg2+-dependent binding of C2 to C4b and the subsequent cleavage of C2 by C1s or MASP2, respectively, the C-terminal fragment C2a consisting of a serine protease and a von Willebrand factor type A domain, remains attached to C4b, forming the C3 convertase, C4b2a, three-dimensional structure of the C2a molecule, residues Asp240, Ser242, Ser244, Thr317 and Asp356 constitute the MIDAS motif of C2a, overview |
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