EC Number   |
Subunits |
Reference |
|---|
   1.14.11.65 | ? |
x * 150000, SDS-PAGE |
753164 |
| 1.14.11.65 | dimer |
2 * 150000, calculated from sequence |
754104 |
| 1.14.11.65 | homodimer |
2 * 150000, SDS-PAGE |
754104 |
| 1.14.11.65 | monomer |
1 * 95059, LSD1 without N-terminal methionine, mass spectrometry |
752751 |
| 1.14.11.65 | More |
domain structure, overview |
-, 755187 |
| 1.14.11.65 | More |
from N- to C-terminus, KDM1A is composed of an unstructured region that contains the nuclear localization signal and three structured domains: a SWI3p, Rsc8p, and Moira (SWIRM) domain, an amine oxidase domain (AOD), and an unprecedented intervening domain within the AOD colloquially known as the tower. The tower domain of KDM1A is composed of two antiparallel alpha-helices (termed TalphaA and TalphaB) that form a coiled coil and extend approximately 100 A from the AOD |
744347 |
| 1.14.11.65 | More |
from N- to C-terminus, KDM1A is composed of an unstructured region that contains the nuclear localization signal and three structured domains: a SWI3p, Rsc8p, and Moira (SWIRM) domain, an amine oxidase domain (AOD), and an unprecedented intervening domain within the AOD colloquially known as the tower. The tower domain of KDM1A is composed of two antiparallel alpha-helices (termed TalphaA and TbetaB) that form a coiled coil and extend approximately 100 A from the amine oxidase domain (AOD) |
744347 |
| 1.14.11.65 | More |
the major functional domains of enzyme HR include a single zinc finger domain, multiple LXXLL motifs that mediate protein-protein interactions, and a JmjC domain in its C-terminus |
744861 |
| 1.14.11.65 | More |
the PHD domain adjacent to the catalytic domain in PHF8 may recognize methyl H3K9 and contribute to its demethylation. PHF8 consists of 16 alpha-helices and 12 beta-strands, arranged in a similar manner to a known JmjC-domain-containing histone demethylase, JHDM1a. In the presence of Fe2+ and 2-oxoglutarate, Fe2+ sits in the center of the c-PHF8 catalytic core, which consists of nine hydrophobic residues |
711703 |
| 1.14.11.65 | More |
two active sites of a JMJD1A dimer are required for effective demethylation |
754104 |
