EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
6.3.2.14 | 6 ATP + 3 2,3-dihydroxybenzoate + 3 L-serine |
overall reaction. EntB, -D, -E, and -F are then required to catalyze the ATP-dependent assembly of enterobactin from three molecules each of 2,3-dihydroxybenzoate and L-serine. EntD, a phosphopantetheinyl transferase, uses coenzyme A to phosphopantetheinylate S245 of the aryl carrier protein domain of EntB. Next, EntE catalyzes the transfer of 2,3-dihydroxybenzoate onto the phosphopantetheinylated (holo) EntB to yield the covalently arylated EntB. Finally, arylated EntB, ATP, and L-serine are used as substrates for the reaction catalyzed by EntF to generate enterobactin |
Escherichia coli |
enterobactin + 6 AMP + 6 diphosphate |
- |
? |
6.3.2.14 | 6 ATP + 3 2,3-dihydroxybenzoate + 3 L-serine |
overall reaction. EntB, -D, -E, and -F are then required to catalyze the ATP-dependent assembly of enterobactin from three molecules each of 2,3-dihydroxybenzoate and L-serine. EntD, a phosphopantetheinyl transferase, uses coenzyme A to phosphopantetheinylate S245 of the aryl carrier protein domain of EntB. Next, EntE catalyzes the transfer of 2,3-dihydroxybenzoate onto the phosphopantetheinylated (holo)EntB to yield the covalently arylated EntB. Finally, arylated EntB, ATP, and L-serine are used as substrates for the reaction catalyzed by EntF to generate enterobactin |
Escherichia coli |
enterobactin + 6 AMP + 6 diphosphate |
- |
? |
6.3.2.14 | ATP + 2,3-dihydroxybenzoate + L-Ser |
- |
Escherichia coli |
Products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-Ser |
- |
? |
6.3.2.14 | ATP + 2,3-dihydroxybenzoate + L-Ser |
specific for the substrates |
Escherichia coli |
Products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-Ser |
- |
? |
6.3.2.14 | ATP + 2,3-dihydroxybenzoate + L-Ser |
specific for the substrates |
Escherichia coli 2276 |
Products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-Ser |
- |
? |
6.3.2.14 | ATP + 2,3-dihydroxybenzoate + L-serine |
- |
Escherichia coli |
N-(2,3-dihydroxybenzoyl)-L-serine + AMP + diphosphate |
- |
? |
6.3.2.14 | ATP + 2,3-dihydroxybenzoate + L-serine |
component of enterobactin synthetase activity that specifically transfers the dihydroxybenzoate acyl group onto holo-entB |
Escherichia coli |
N-(2,3-dihydroxybenzoyl)-L-serine + AMP + diphosphate |
- |
? |
6.3.2.14 | ATP + 2,3-dihydroxybenzoate + phosphopantetheinylated EntB |
reaction of EntE |
Escherichia coli |
arylated EntB + AMP + diphosphate |
- |
? |
6.3.2.14 | ATP + 3-hydroxybenzoate + phosphopantetheinylated EntB |
reaction of EntE |
Escherichia coli |
arylated EntB + AMP + diphosphate |
- |
? |
6.3.2.14 | ATP + 4-aminosalicylic acid + phosphopantetheinylated EntB |
reaction of EntE |
Escherichia coli |
arylated EntB + AMP + diphosphate |
- |
? |