EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
6.2.1.26 | 4-[2-(trifluoromethyl)phenyl]-4-oxobutyric acid + CoA |
a substrate analogue, 100fold less active than 2-succinylbenzoate |
Bacillus anthracis |
AMP + diphosphate + 4-[2-(trifluoromethyl)phenyl]-4-oxobutyryl-CoA |
- |
? |
6.2.1.26 | ATP + 2-succinylbenzoate + CoA |
- |
Escherichia coli |
AMP + diphosphate + 2-succinylbenzoyl-CoA |
- |
? |
6.2.1.26 | ATP + 2-succinylbenzoate + CoA |
- |
Mycolicibacterium phlei |
AMP + diphosphate + 2-succinylbenzoyl-CoA |
- |
? |
6.2.1.26 | ATP + 2-succinylbenzoate + CoA |
- |
Synechocystis sp. |
AMP + diphosphate + 2-succinylbenzoyl-CoA |
- |
? |
6.2.1.26 | ATP + 2-succinylbenzoate + CoA |
- |
Arabidopsis thaliana |
AMP + diphosphate + 2-succinylbenzoyl-CoA |
- |
? |
6.2.1.26 | ATP + 2-succinylbenzoate + CoA |
- |
Escherichia coli |
AMP + diphosphate + 2-succinylbenzoyl-CoA |
o-succinylbenzoyl-CoA is a highly unstable compound which spontaneously converts to o-succinylbenzoate-spirolactone in absence of 1,4-dihydroxy-2-naphthoic acid synthase |
? |
6.2.1.26 | ATP + 2-succinylbenzoate + CoA |
- |
Mycolicibacterium phlei |
AMP + diphosphate + 2-succinylbenzoyl-CoA |
the o-succinylbenzoyl conenzyme A ester is unstable at alkaline and neutral pH, but is fairly stable under acid conditions |
? |
6.2.1.26 | ATP + 2-succinylbenzoate + CoA |
- |
Mycolicibacterium phlei |
AMP + diphosphate + 2-succinylbenzoyl-CoA |
incubation of the purified enzyme at different pH values gives a varying ratio of o-succinylbenzoyl-CoA to o-succinylbenzoyl-diCoA. No formation of o-succinylbenzoyl-2-CoA. No formation of ADP |
? |
6.2.1.26 | ATP + 2-succinylbenzoate + CoA |
- |
Mycolicibacterium phlei |
AMP + diphosphate + 2-succinylbenzoyl-CoA |
the o-succinylbenzoyl-CoA derivative is rather unstable, under a variety of conditions it is converted to a spirodilactone form of o-succinylbenzoate |
? |
6.2.1.26 | ATP + 2-succinylbenzoate + CoA |
o-succinylbenzoyl-CoA is an intermediate in menaquinone (vitamin K2) biosynthesis |
Escherichia coli |
AMP + diphosphate + 2-succinylbenzoyl-CoA |
- |
? |